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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of design, including the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and participants from various geographical areas. This kind of heterogeneity, which is vital for a pragmatic trial to be valid and to reduce bias in the results is also essential. Too much heterogeneity, however, can cause problems with the trial design.

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The aim of pragmatic trials is to simulate real-life scenarios and 프라그마틱 무료슬롯 gain the highest level of validity externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. However, they should not be used in lieu for explanatory studies.

The concept of pragmatism is controversial, 프라그마틱 공식홈페이지 and there are questions about whether pragmatic trials should replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study that includes recruitment, design, delivery of the intervention and follow-up.

There is a growing increase in the number pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.