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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of study design, such as the recruitment and consent process as well as adherence to the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from various geographical areas. This kind of heterogeneity is essential for pragmatic trials to be valid, and it also helps reduce bias in the results. However, too much heterogeneity can result in issues with the design of the trial.

Pragmatic Play is also a major player in the live casino market, providing a wide selection of table games that are classic such as Blackjack and Roulette in various variations. Pragmatic Play's live studios in Romania and Malta offer a real-life gambling experience for customers and offer an extensive selection of virtual betting options. The company also has several game shows that make online gambling enjoyable and engaging. Some of these shows are broadcast live and some are hosted by famous personalities from the field.

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Pragmatic Play, a relatively young player in the industry of casinos online, has earned recognition for its mobile-friendly slot machines. Their games are optimized for mobile devices and are powered by HTML5 technology. They're also endorsed by reputable gaming authorities to ensure fairness and transparency. This is a good sign for players as it indicates that the games have been thoroughly tested and verified in order to ensure the randomness and unbiased results of every round.

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Legality

Pragmatic Play is known for its top-notch games, and for offering an exceptional user experience. Its software is designed to work on mobile devices and is compatible with various languages. Despite its relative youth it has already established itself as a premier casino gaming platform. Its latest releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually requested by policy makers and practitioners to aid in their decision-making. They also provide a useful way to identify the causality between the intervention and its effects. However, they shouldn't be used in lieu for explanatory studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, and follow-up.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.