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Use vitamin D cautiously if you're taking medication processed by these enzymes. Digoxin (Lanoxin). Avoid taking excessive doses of vitamin D with this coronary heart remedy. High doses of vitamin D can cause hypercalcemia, which will increase the danger of fatal heart issues with digoxin. Diltiazem (Cardizem, Tiazac, others). Avoid taking excessive doses of vitamin D with this blood strain drug. Signs of low vitamin D levels can embrace fatigue, muscle pain or weakness, bone pain, depression, and cognitive impairment. Learn Extra What's Vitamin D deficiency? Mohammad S, Mishra A, Ashraf MZ. Rising function of vitamin d and its associated molecules in pathways related to pathogenesis of thrombosis. Nationwide Institutes of Well being.